Formulation and evaluation of lansoprazole orodispersable tablets using novel excipients

In the present work an attempt has been made to increase the solubility and dissolution rate of lansprozole by formulating it as solid dispersions by lipid carriers such as compritol 888 ATO Phospholipon 90 H and Lipoid S100 by using Fusion method, Kneading method and solvent evaporation method. Further the solid dispersions were compressed as orodispersible tablets by using croscarmelloe sodium (CCS) & sodium starch glycolate (SSG) as superdisintegrants. Rapid release of lansoprazole from solid dispersions was observed which was influenced by the proportion of carrier concentration. Among the solid dispersions prepared the dispersion formulated using Phospholipon 90 H showed rapid drug release than compritol 888 ATO & Lipoid S100 containing Solid dispersions and pure drug alone. The release was found to follow the first order kinetics. Solid dispersions prepared by the various methods were further formulated into tablets with superdisintegrants such as sodium starch glycolate (SSG) & crospovidone (CP) The dissolution rate of such tablet formulations were found to release the drug at a faster rate than the tablets prepared with plain drug. Characterization was carried out by pure drug (Lansprozol) and optizimed formulation L6 by FTIR and DSC Studies. The Studies shows that there was no drug and polymer interaction.